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[Cancer risk under hormone therapy]

C Lauritzen1

  • 1Universitäts-Frauenklinik Ulm.

Therapeutische Umschau. Revue Therapeutique
|November 1, 1994
PubMed
Summary

Estrogen therapy can stimulate cell growth, but progestogens prevent cancer by reducing estrogen receptors and promoting tissue function. Combined hormone therapy may reduce cancer risk and improve outcomes in postmenopausal women.

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Area of Science:

  • Endocrinology and Oncology
  • Hormone Replacement Therapy Research
  • Cancer Prevention Strategies

Context:

  • Estrogens stimulate target organ cell division, potentially promoting early neoplastic changes.
  • Progestogens counteract estrogen's proliferative effects by altering receptor levels and cellular metabolism.
  • Hormonal influences on cancer development are dose-dependent and influenced by various risk factors.

Purpose:

  • To evaluate the role of estrogens and progestogens in cancer development and prevention.
  • To assess the impact of combined hormone therapy on cancer risk and prognosis.
  • To determine the safety and efficacy of hormone substitution in cancer survivors.

Summary:

  • Estrogens promote cell growth, while progestogens inhibit proliferation and induce tissue function, acting preventively against genital and breast cancers.
  • Combined estrogen-progestogen therapy may reduce the risk of endometrial, ovarian, breast, and colon cancers.
  • Hormone therapy is increasingly considered safe and potentially beneficial for cancer survivors, even those with hormone-receptor-negative cancers.

Impact:

  • Estrogen-progestogen therapy can lower the incidence of certain cancers and improve prognosis for those who develop them.
  • The contraindication for hormone therapy in post-carcinoma patients is being re-evaluated, with potential benefits for cure rates and survival.
  • Personalized hormone therapy, using appropriate doses and combinations, is recommended for cancer prevention and management.

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