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Acute 2,4-dichlorophenoxyacetic acid intoxication in cattle

C A Paulino¹, G H Oliveira, J Palermo-Neto

¹Research Center for Veterinary Toxicology (CEPTOX), School of Veterinary Medicine, University of Sao Paulo, Brazil.

Veterinary and Human Toxicology

|October 1, 1994

Summary

Acute toxicity studies of 2,4-dichlorophenoxyacetic acid (2,4-D) in cattle show minimal effects. Cattle rapidly excreted the herbicide, with intoxication signs fully reversing, indicating low toxicological risk in grazing systems.

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Area of Science:

Veterinary Toxicology
Agricultural Science

Background:

2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide.
Understanding its toxicological impact on livestock is crucial for agricultural safety.

Purpose of the Study:

To evaluate the acute toxicity of 2,4-D in cattle.
To determine the effects of different dosages on physiological and behavioral parameters.

Main Methods:

Oral administration of 2,4-D at 100, 300, or 600 mg/kg to steers.
Monitoring of behavioral, physiological (heart rate, respiration, temperature), and ruminal functions.
Analysis of blood and urine samples for 2,4-D levels and other indicators.

Main Results:

No significant alterations in vital functions or hematocrit were observed.

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Dose- and time-dependent motor alterations, decreased ruminal movements, and proteinuria were noted.

Rapid excretion of 2,4-D and complete reversal of clinical signs.

Conclusions:

2,4-D exhibits low acute toxicity in cattle.
The herbicide is rapidly eliminated, and intoxication signs are reversible.
Minimal toxicological consequences are expected for cattle in natural grazing systems.