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[Resistance to activated protein C, so-called APC resistance: the first two cases in Slovakia]

J Hudecek1, J Ivánková, P Kubisz

  • 1Klinika hematológie a transfuziológie MFN Martin.

Vnitrni Lekarstvi
|December 1, 1994
PubMed

Insights

Activated protein C (APC) resistance, a common cause of thrombophilia linked to factor V, requires a newly identified cofactor besides protein S. This study reports the first diagnosed cases of APC resistance in Slovakia.

Area of Science:

  • Biochemistry
  • Hematology
  • Genetics

Background:

  • The anticoagulant function of activated protein C (APC) is crucial for hemostasis.
  • Protein S is a known cofactor for APC, but another essential cofactor has been identified.

Observation:

  • Deficiency of this newly detected cofactor leads to APC resistance.
  • APC resistance is strongly associated with the factor V molecule.
  • This defect is recognized as the most prevalent cause of thrombophilia.

Findings:

  • Two patients diagnosed with APC resistance are presented.
  • These represent the first documented cases of APC resistance in Slovakia.

Implications:

  • Understanding APC resistance is vital for diagnosing and managing thrombophilia.
  • Identification of APC resistance in Slovakia expands the geographical scope of this condition.
  • Further research into the novel cofactor may reveal new therapeutic targets for thrombotic disorders.

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