[Metabolism of the basic component of connective tissue at various stages of developing experimental liver cirrhosis]

A system of GAG-hydrolase was studied in liver tissue and blood plasma during development of CCl4-produced cirrhosis of liver tissue in series of experiments involving 400 adult rat males. Dissimilar pathways of the matrix formation, related to dynamics of the GAG-hydrolases activity, were detected within various steps of the chronic CCL4-produced liver tissue impairments in these rats. Alterations in the enzymatic activity were stable and regular in each series of the experiment and correlated with dynamics of the adaptation-compensatory responses.