[Ubiquinones and the body's antimutagenic defense]

The effects of ubiquinone-10 given in oral doses of 0.2-20 mg/kg on cytogenetic effects of intraperitoneal photrinum (7 and 14 mg/kg), dioxydinum (100 and 300 mg/kg) and cyclophosphanum (20 mg/kg) were studied in the bone marrow metaphasic cells of male C57Bl/6 mice. Ubiquinone-10 (2 to 20 mg/kg) statistically significantly reduced the clastogenic action of these mutagens, except photrinum used in a dose of 7 mg/kg. The antimutagenic effect of the drug was dose-independent and no more than 50%. The findings enable ubiquinone-10 be considered as an endogenous antimutagen. It is suggested that the antimutagenic activity of the compound is due to its antioxidative properties.