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Sodium lactate response and familial risk for panic disorder
A H Reschke1, S Mannuzza, T F Chapman
1Department of Therapeutics, New York State Psychiatric Institute, New York.
The American Journal of Psychiatry
|February 1, 1995
Summary
This study found no evidence that sodium lactate response differentiates panic disorder subtypes. Familial transmission rates of panic disorder were similar across patient groups, suggesting lactate sensitivity is not linked to distinct panic disorder types.
Area of Science:
- Psychiatry
- Genetics
- Clinical Psychology
Background:
- Panic disorder is a significant mental health condition.
- The potential existence of panic disorder subtypes remains an area of research interest.
- Sodium lactate infusion is known to provoke panic attacks in susceptible individuals.
Purpose of the Study:
- To investigate whether sodium lactate response can be used to identify distinct subtypes of panic disorder.
- To examine the familial transmission patterns of panic disorder in relation to lactate sensitivity.
Main Methods:
- The study employed a family study design.
- Researchers compared the rates of panic disorder in first-degree relatives of patients who responded to sodium lactate versus those who did not.
- A control group of relatives from never-mentally ill subjects was also included.
Main Results:
- No significant differences in the familial rates of panic disorder were observed between the first-degree relatives of sodium lactate responders and non-responders.
- These findings indicate similar patterns of genetic or environmental influences on panic disorder in both patient groups.
Conclusions:
- The study's results do not support the hypothesis that panic disorder can be classified into subtypes based on sensitivity to sodium lactate.
- Lactate sensitivity does not appear to be a reliable marker for differentiating panic disorder subtypes in terms of familial aggregation.