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Related Experiment Videos

Human milk fortifiers

P Guerrini1

  • 1Department of Pediatrics, University of Ferrara, Italy.

Acta Paediatrica (Oslo, Norway : 1992). Supplement
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Fortifying human milk with a cow's milk-based supplement supports optimal growth in very low birthweight infants. This method offers a practical alternative to complex nutritional strategies for preterm infant feeding.

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Area of Science:

  • Neonatal Nutrition
  • Pediatric Gastroenterology
  • Infant Growth and Development

Background:

  • Unsupplemented human milk is often insufficient in protein and minerals for optimal growth in low birthweight infants.
  • Premature infants require specialized nutritional support to meet their high metabolic demands.
  • Existing methods for optimizing infant nutrition can be complex or less accessible.

Purpose of the Study:

  • To compare the growth and biochemical status of very low birthweight infants fed fortified human milk versus high-caloric-density formula.
  • To evaluate the efficacy of a novel human milk fortifier composed of cow's milk proteins and amino acids.
  • To assess the feasibility and acceptability of milk fortification as a nutritional strategy.

Main Methods:

  • A comparative study involving 21 very low birthweight infants.

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  • Group 1: Seven infants fed their own mothers' fortified milk.
  • Group 2: 14 infants fed a high-caloric-density formula.
  • The human milk fortifier comprised 40% whey, 45% casein, and 15% amino acids.
  • Assessment of growth parameters and biochemical status in both groups.

    • Main Results:

    • Infants receiving fortified human milk demonstrated growth and biochemical profiles comparable to those fed high-caloric-density formula.
    • The plasma amino acid profile in infants on fortified milk was similar to that of infants exclusively fed unsupplemented human milk.
    • The fortification method proved easy to perform and acceptable.

    Conclusions:

    • Supplementing human milk with the described cow's milk-based fortifier is an effective strategy for supporting the growth of very low birthweight infants.
    • This fortification approach provides a viable and practical alternative to more complex nutritional interventions like 'lacto-engineering'.
    • The findings support the use of fortified human milk as a beneficial nutritional option for preterm infants.