Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Modified hemoglobin solutions as artificial oxygen carriers]

G Lenz1, U Bissinger

  • 1Abteilung Anaesthesiologie, Universität Tübingen.

Infusionstherapie Und Transfusionsmedizin
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neoadjuvant immune checkpoint inhibitors for localized dMMR/MSI-H gastric cancer: a meta-analysis.

ESMO open·2026
Same author

Correction to: The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis.

Journal of neurology·2022
Same author

The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis.

Journal of neurology·2022
Same author

Recent developments in drug delivery strategies for targeting DNA damage response in glioblastoma.

Life sciences·2021
Same author

Radiation treatment of hemato-oncological patients in times of the COVID-19 pandemic : Expert recommendations from the radiation oncology panels of the German Hodgkin Study Group and the German Lymphoma Alliance.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2020
Same author

Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity.

Stem cell reviews and reports·2020
Same journal

Determination and Successful Transfusion of Anti-Gerbich-Positive Red Blood Cells in a Patient with a Strongly Reactive Anti-Gerbich Antibody.

Infusionstherapie und Transfusionsmedizin·2000
Same journal

Coexisting Anti-I/i Plus Anti Pr Cold Agglutinins in Individual Sera.

Infusionstherapie und Transfusionsmedizin·2000
Same journal

Comparison of Solvent/Detergent-Inactivated Plasma and Fresh Frozen Plasma under Routine Clinical Conditions.

Infusionstherapie und Transfusionsmedizin·2000
Same journal

Transfusion-Associated Infections with Cytomegalovirus and Other Human Herpesviruses.

Infusionstherapie und Transfusionsmedizin·2000
Same journal

Arificial Oxygen Carriers as Red Blood Cell Substitutes - Perfluorocarbons and Cell-Free Hemoglobin.

Infusionstherapie und Transfusionsmedizin·2000
Same journal

Platelet Concentrates from Automated Apheresis - Past, Present and Future Developments.

Infusionstherapie und Transfusionsmedizin·2000
See all related articles

Modified hemoglobin (Hb) solutions show promise as plasma substitutes, overcoming limitations like oxygen affinity and persistence. Research efforts aim to realize these oxygen-carrying Hb solutions for medical use.

Area of Science:

  • Biochemistry and Biotechnology
  • Colloid Science
  • Medical Engineering

Context:

  • Hemoglobin (Hb) solutions are theoretically ideal colloidal plasma substitutes due to their oxygen-carrying capacity.
  • Limitations of cell-free Hb include high oxygen affinity and poor intravascular persistence.
  • Current research explores various modifications to enhance Hb efficacy and safety.

Purpose:

  • To provide an overview of the development and current status of modified hemoglobin (Hb) preparations.
  • To discuss methods for overcoming the limitations of extraerythrocytic Hb.
  • To evaluate the potential of modified Hb solutions as oxygen-transporting plasma substitutes.

Summary:

  • Modified Hb preparations can be derived from human/bovine erythrocytes, recombinant DNA technology (yeast, bacteria, transgenic animals).

Related Experiment Videos

  • Modifications like intramolecular stabilization, macromolecule linking, cross-linking (PolyHb), and microencapsulation improve intravascular persistence.
  • Lowering oxygen affinity via allosteric modulators (e.g., pyridoxal phosphate) or using intrinsically low-affinity bovine Hb addresses another key limitation.
  • Pyridoxylated PolyHb and bovine PolyHb solutions meet criteria for blood volume maintenance and oxygen capacity, though vasoconstrictive and renal effects require further attention.

    • Impact:

    • Modified Hb solutions, particularly PolyHb, demonstrate potential as oxygen carriers, fulfilling key requirements for plasma substitutes.
    • Ongoing research and industrial efforts suggest the future realization of Hb-based oxygen carriers.
    • Addressing concerns regarding vasoconstriction and renal toxicity is crucial for clinical application.