Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic function in systemic lupus erythematosus

R Omdal1, R Jorde, S I Mellgren

  • 1Department of Rheumatology, University Hospital of Tromsø, Norway.

Lupus
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperglycemia, assessed according to HbA1c , and future risk of venous thromboembolism: the Tromsø study.

Journal of thrombosis and haemostasis : JTH·2014
Same author

Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study.

Andrology·2013
Same author

Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients.

European journal of neurology·2013
Same author

Supplementation with vitamin D does not increase serum testosterone levels in healthy males.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2013
Same author

Serum levels of vitamin D are not associated with future risk of venous thromboembolism. The Tromsø Study.

Thrombosis and haemostasis·2013
Same author

Glycated hemoglobin in diagnosis of diabetes mellitus and pre-diabetes; validation by oral glucose tolerance test. The Tromsø OGTT Study.

Journal of endocrinological investigation·2011
Same journal

Association of systemic lupus erythematosus with 90-day readmission following heart failure hospitalization: A national readmission database (NRD) analysis, 2016-2017.

Lupus·2026
Same journal

Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus.

Lupus·2026
Same journal

Giant cell myocarditis in an 18-year-old patient with new-onset systemic lupus erythematosus: A fatal case of rapidly progressing heart failure.

Lupus·2026
Same journal

An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research.

Lupus·2026
Same journal

T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus.

Lupus·2026
Same journal

Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis.

Lupus·2026
See all related articles

Systemic lupus erythematosus (SLE) did not significantly affect autonomic function based on cardiovascular tests. However, pancreatic polypeptide response was unexpectedly increased in SLE patients, warranting further investigation.

Area of Science:

  • Immunology
  • Autonomic Nervous System Physiology
  • Gastroenterology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with potential systemic effects.
  • Autonomic nervous system (ANS) dysfunction can occur in various autoimmune conditions.
  • The role of ANS dysfunction in SLE pathogenesis remains incompletely understood.

Purpose of the Study:

  • To investigate autonomic function in patients with systemic lupus erythematosus (SLE).
  • To assess cardiovascular and pancreatic polypeptide responses as indicators of autonomic function in SLE.

Main Methods:

  • A controlled study comparing 34 SLE patients with 34 age and sex-matched healthy controls.
  • Standardized cardiovascular tests were used to evaluate autonomic function.

Related Experiment Videos

  • Pancreatic polypeptide (PP) response to meal stimulation was measured.

    • Main Results:

    • Standardized cardiovascular tests showed no significant autonomic dysfunction in SLE patients.
    • Pancreatic polypeptide (PP) response to meal stimulation was significantly increased in SLE patients, both unstimulated and stimulated.
    • Neither cardiovascular nor serological tests revealed significant autonomic dysfunction directly attributable to SLE.

    Conclusions:

    • Autonomic function, assessed by cardiovascular tests, appears largely preserved in SLE patients.
    • Elevated pancreatic polypeptide (PP) response in SLE patients requires further investigation to determine its cause.
    • Medications with cardiovascular effects can influence autonomic function tests and may confound results in SLE patients.