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[Hyperglycemia revealing neonatal infection]
D Louaib1, E Lachassinne, M Nathanson
1Service de pédiatrie, hôpital Jean-Verdier, Bondy, France.
Summary
Neonatal sepsis can rarely present with hyperglycemia. Early detection of high blood sugar in newborns may lead to prompt diagnosis and treatment of serious infections like group B streptococcal disease.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Endocrinology
Background:
- Neonatal sepsis is a serious infection in newborns.
- Hyperglycemia is an uncommon initial sign of neonatal sepsis.
- Group B Streptococcus (GBS) is a significant neonatal pathogen.
Observation:
- A 6-day-old neonate presented with vomiting and hyperglycemia (9.7 mmol/l) with glucosuria.
- Initial ear secretions at birth showed GBS, but the neonate was not treated.
- Physical examination was normal upon admission.
Findings:
- Blood, spinal fluid, and urine cultures confirmed GBS infection.
- Elevated blood fibrinogen and C-reactive protein supported the diagnosis of sepsis.
- Hyperglycemia and glucosuria resolved within 24 hours of antibiotic treatment.
Implications:
- Isolated hyperglycemia in neonates can be an indicator of underlying infection.
- Prompt identification of hyperglycemia may facilitate early diagnosis of neonatal sepsis.
- Timely antibiotic therapy is crucial for managing GBS sepsis and resolving hyperglycemia.