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Primary colorectal non-Hodgkin's lymphoma
E Busch1, M Rodriguez-Bigas, E Mamounas
1Department of Surgical Oncology and Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263.
Annals of Surgical Oncology
|May 1, 1994
Summary
Primary colorectal non-Hodgkin's lymphoma (NHL) affects both children and adults. Pediatric patients show excellent prognosis, while adult survival rates approach 50% with multimodality treatment.
Area of Science:
- Gastroenterology
- Oncology
- Hematology
Background:
- The gastrointestinal tract is a frequent site for extranodal non-Hodgkin's lymphoma (NHL).
- Primary colorectal NHL, though less commonly reported, constitutes a significant portion of gastrointestinal NHL cases.
Purpose of the Study:
- To evaluate the clinical features and behavior of primary colorectal non-Hodgkin's lymphoma (NHL).
- To compare outcomes between pediatric and adult patients diagnosed with colorectal NHL.
Main Methods:
- Retrospective review of medical records for 19 patients diagnosed with colorectal NHL over a 16-year period.
- Analysis of clinical presentation, staging results, treatment modalities, and patient survival.
Main Results:
- Pediatric patients (7 males) presented early with acute symptoms, ileocecal tumors, and intussusception; their median survival exceeded 72 months.
- Adult patients (12) presented later with chronic symptoms; staging revealed varying detection rates (bone marrow biopsy 25%, lymph-angiography 54.5%, gallium scan 80%).
- Overall median survival was 45 months, with 50% of adult patients achieving long-term survival; relapse occurred in 7 patients.
Conclusions:
- Colorectal NHL impacts both pediatric and adult populations, with distinct clinical presentations and prognoses.
- Pediatric patients generally experience excellent long-term survival following treatment.
- Multimodality therapy, including surgery, chemotherapy, and radiation, is the recommended treatment for colorectal NHL in both age groups.