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Bronchopneumonia caused by Propionibacterium acnes
G Claeys1, G Verschraegen, C De Potter
1Department of Bacteriology, University Hospital, Ghent, Belgium.
Abstract:
Propionibacterium acnes was identified as the pathogen in a case of subacute lung infection by examination of an open lung biopsy specimen. The patient was a 65-year-old male with exacerbation of chronic lung disease. The organism was isolated in pure culture and was present in large numbers on Gram stain. Histological examination demonstrated active interstitial fibrosis; macrophages laden with Propionibacterium acnes antigen were revealed using a peroxidase-antiperoxidase stain. This is the first report of subacute infection of pulmonary tissue due to this organism.
Insights
Propionibacterium acnes caused a rare subacute lung infection in a patient with chronic lung disease. This case highlights a new pulmonary pathogen, Propionibacterium acnes, in interstitial fibrosis.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Microbiology
Background:
- Subacute lung infections can be challenging to diagnose.
- Chronic lung disease exacerbations may present with diverse etiologies.
- Identifying causative pathogens is crucial for effective treatment.
Observation:
- A 65-year-old male with chronic lung disease exacerbation presented with subacute respiratory symptoms.
- Open lung biopsy revealed interstitial fibrosis.
- Gram stain showed numerous bacteria, later identified as Propionibacterium acnes.
Findings:
- Propionibacterium acnes was isolated in pure culture from lung tissue.
- Macrophages within the biopsy stained positive for Propionibacterium acnes antigen.
- Histopathology confirmed active interstitial fibrosis associated with the bacterial presence.
Implications:
- This is the first documented case of subacute pulmonary infection caused by Propionibacterium acnes.
- The findings expand the spectrum of lung infections associated with this bacterium.
- Further research is warranted to understand the pathogenesis and clinical significance of Propionibacterium acnes in lung disease.