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Related Experiment Videos

Gender differences and the electrocardiogram in left ventricular hypertrophy

P M Okin1, M J Roman, R B Devereux

  • 1Department of Medicine, New York Hospital-Cornell Medical Center, NY 10021.

Hypertension (Dallas, Tex. : 1979)
|February 1, 1995
PubMed
Summary
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Men exhibit distinct electrocardiogram (ECG) voltage and QRS duration differences compared to women. These ECG criteria for left ventricular hypertrophy show lower accuracy in women, even after adjustments.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Electrocardiogram (ECG) measurements vary between sexes.
  • Existing ECG criteria for left ventricular hypertrophy (LVH) may not be universally applicable.
  • Understanding gender-specific differences is crucial for accurate cardiac assessment.

Purpose of the Study:

  • To investigate gender disparities in ECG voltage and QRS duration.
  • To correlate these ECG findings with cardiac dimensions and body size.
  • To evaluate the performance of ECG criteria for detecting LVH across genders.

Main Methods:

  • Analysis of ECG parameters (QRS duration, voltages, voltage-duration products) in 389 subjects (112 women, 277 men).
  • Comparison of ECG findings between men and women, with and without echocardiographic LVH.

Related Experiment Videos

  • Adjustment for body size (height, weight) and left ventricular mass.
  • Receiver operating characteristic (ROC) curve analysis to assess diagnostic performance.

    • Main Results:

    • Men consistently showed longer QRS duration and higher voltage measurements than women, irrespective of LVH status.
    • Significant gender differences persisted after adjusting for body size and left ventricular mass.
    • ECG criteria for LVH identification demonstrated superior performance in men compared to women.

    Conclusions:

    • Gender differences in body size and left ventricular mass do not fully explain variations in ECG measurements.
    • Current ECG criteria for left ventricular hypertrophy exhibit reduced accuracy in women.
    • Gender-specific ECG criteria may be necessary for improved detection of LVH in women.