Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression

B Jiang1, G I Liou, M A Behzadian

  • 1Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000.

Journal of Cell Science
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity-driven thyroid cancer burden in middle-aged and older populations: temporal trends and projected trajectories based on the Global Burden of Disease study.

Hong Kong medical journal = Xianggang yi xue za zhi·2026
Same author

Separate Exact Laws of Kinetic and Magnetic Energy Cascade in Magnetohydrodynamic Turbulence.

Physical review letters·2026
Same author

A comparative study of vessel length measurements in branches of eight subtropical woody species based on three methods.

Plant biology (Stuttgart, Germany)·2026
Same author

Izalontamab brengitecan (Iza-bren; BL-B01D1), a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, for patients with EGFR-mutated NSCLC: pooled analysis of phase I and phase II trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

[Clinical efficacy of 12 o'clock peripheral iridectomy in aphakic eyes undergoing pars plana vitrectomy with heavy silicone oil tamponade].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same author

The use of coronary computed tomography angiography (CCTA) to predict coronary artery plaque, with a focus on new, high-risk, and obstructive plaques.

Clinical radiology·2025

Astrocytes initiate retinal vasculogenesis by promoting fibronectin expression in the extracellular matrix. This study reveals fibronectin

Area of Science:

  • Developmental biology
  • Cell biology
  • Ophthalmology

Background:

  • Vasculogenesis, the formation of new blood vessels, is crucial for tissue development.
  • Astrocytes, glial cells in the central nervous system, are increasingly recognized for their roles beyond neural support.
  • The extracellular matrix (ECM) plays a vital role in cell behavior and tissue formation.

Purpose of the Study:

  • To investigate the role of astrocytes in retinal vasculogenesis.
  • To determine the influence of astrocytes on ECM composition during blood vessel formation.
  • To elucidate the temporal relationship between astrocyte migration, ECM protein expression, and vessel development.

Main Methods:

  • In vivo studies using neonatal rat retinas to observe astrocyte migration and ECM protein expression.

Related Experiment Videos

  • Analysis of fibronectin and laminin expression in relation to blood vessel formation.
  • In vitro experiments using conditioned media to assess astrocyte-endothelial cell interactions.

    • Main Results:

    • Astrocytes migrate into the retina preceding new blood vessel formation, suggesting a role in initiating vasculogenesis.
    • Fibronectin, but not laminin, is expressed in the zone of active vasculogenesis before vessel formation.
    • Astrocytes stimulate endothelial cell fibronectin expression in vitro, and fibronectin mRNA increases in vivo during vasculogenesis.

    Conclusions:

    • Astrocytes play a critical role in initiating retinal vasculogenesis.
    • Fibronectin expression, stimulated by astrocytes, is essential for the early stages of blood vessel formation.
    • Fibronectin expression precedes laminin expression during retinal vasculogenesis, highlighting a sequential ECM remodeling process.