Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin-induced decrease of body temperature in women: a threshold event

A Cagnacci1, R Soldani, C Romagnolo

  • 1Department of Reproductive Medicine, University of California, San Diego School of Medicine, La Jolla.

Neuroendocrinology
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experts' view on the role of oestrogens in combined oral contraceptives: emphasis on oestetrol (E4).

Frontiers in global women's health·2024
Same author

Clinical and ultrasonographic characteristics of pregnancy-related enhanced myometrial vascularity: prospective cohort study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Omental incarceration in uterine perforation: from diagnosis to therapy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Relation between adenomyosis and elastographic characteristics of the cervix.

Human reproduction (Oxford, England)·2023
Same author

Vaginal oxygen plus hyaluronic acid on genito-urinary symptoms of breast cancer survivors.

Climacteric : the journal of the International Menopause Society·2023
Same author

Relation between blood pressure and genito-urinary symptoms in the years across the menopausal age.

Climacteric : the journal of the International Menopause Society·2022
Same journal

Passive Smoking and Thyroid Diseases: Association by Mendelian Randomization Study.

Neuroendocrinology·2026
Same journal

Erratum.

Neuroendocrinology·2026
Same journal

Stress as a Neuroendocrine Modulator of the Reproductive Axis: Roles of Glucocorticoids, Kisspeptin and Serotonergic Signalling in Animal Models.

Neuroendocrinology·2026
Same journal

Pathological Classification and Clinical Characteristics of Growth Hormone-Secreting PitNETs.

Neuroendocrinology·2026
Same journal

Proximal-to-distal gradient and its implications in differentiation and prognosis in colorectal neuroendocrine neoplasms: the RGETNE-HERACLES study.

Neuroendocrinology·2026
Same journal

Inflammatory Signaling and Emotional Symptoms in Hashimoto's Thyroiditis Beyond Thyroid Function Status.

Neuroendocrinology·2026
See all related articles

Melatonin

Area of Science:

  • Endocrinology
  • Chronobiology
  • Human Physiology

Background:

  • Melatonin's biological effects in humans and their relation to circulating levels remain under investigation.
  • Previous studies suggest melatonin has hypothermic properties, but a dose-response relationship has not been established.

Purpose of the Study:

  • To investigate if the hypothermic effect of melatonin in humans is dose-dependent.
  • To determine the relationship between circulating melatonin levels and body temperature regulation.

Main Methods:

  • 16 women in the early follicular phase received placebo, atenolol (a beta-1 adrenergic antagonist), or atenolol plus melatonin.
  • Nocturnal body temperature decline was compared across conditions.
  • Melatonin levels were measured to assess suppression and restoration.

Related Experiment Videos

Main Results:

  • Atenolol completely suppressed melatonin in 37.5% of subjects, attenuating nocturnal body temperature decline.
  • Incomplete melatonin suppression occurred in 62.5% of subjects, with no change in body temperature decline.
  • Exogenous melatonin restored body temperature decline in those with complete suppression, but not in those with incomplete suppression.

Conclusions:

  • Melatonin's thermoregulatory effect in humans appears to be threshold-dependent rather than dose-dependent.
  • Markedly attenuated, but not completely suppressed, nocturnal melatonin levels are sufficient for maximal thermoregulatory effects.