Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Case Studies

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Study Designs in Epidemiology

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...

Observational Studies

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...

Bias in Epidemiological Studies

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

Introduction to Epidemiology

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Consensus Conference on the Treatment of in situ Ductal Carcinoma of the Breast, 22-25 April 1999.

Breast (Edinburgh, Scotland)·2004

Same author

Effect of variations in operational definitions on performance estimates for screening mammography.

Academic radiology·2000

Same author

Women should be fully informed of the potential benefits and harms before screening mammography.

The Western journal of medicine·2000

Same author

Current medicolegal and confidentiality issues in large, multicenter research programs.

American journal of epidemiology·2000

Same author

[The consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22-25, 1999].

Bulletin du cancer·2000

Same author

Spit (smokeless) tobacco use by high school baseball athletes in California.

Tobacco control·2000

Same journal

Who bears the responsibility? Perceptions of responsibility for eating healthily and sustainably in a representative German sample.

Preventive medicine·2026

Same journal

Behavioral economic demand analysis: A multidimensional framework for understanding drug reinforcement and tobacco science.

Preventive medicine·2026

Same journal

Corrigendum to 'Differential associations of objective hearing loss and subjective hearing difficulty with depressive symptom profiles: A nationwide population-based study in Korea' [Preventive Medicine 210 (2026) 108620].

Preventive medicine·2026

Same journal

Adverse childhood experiences and household firearm ownership: A large-scale analysis of specific risk factors among 15,771 adults from four U.S. states.

Preventive medicine·2026

Same journal

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Preventive medicine·2026

Same journal

Employment insecurity and binge drinking in the United States: Implications of unemployment insurance.

Preventive medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 3, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Nested case-control studies

¹Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143-0560.

Preventive Medicine

|September 1, 1994

Summary

This summary is machine-generated.

The nested case-control study design offers cost savings and efficiency for disease research compared to full cohort studies. This method is especially useful for identifying disease precursors and advancing prevention research.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Mar 3, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Epidemiology
Biostatistics

Background:

The nested case-control study design is a valuable epidemiological tool.
It involves selecting controls from a defined cohort after cases have been identified.

Purpose of the Study:

To describe and compare the nested case-control study design with other epidemiological study designs.
To highlight the advantages of the nested case-control design for specific research questions, particularly in disease prevention.

Main Methods:

Description of the nested case-control methodology, where cases are identified within a cohort.
Matching of controls to cases from the same cohort based on non-disease status at the time of case diagnosis.
Comparison with classic case-control, cohort, and case-cohort study designs.

Main Results:

Nested case-control studies offer significant reductions in data collection and analysis costs compared to full cohort studies.
This design provides substantial statistical efficiency with minimal loss compared to the cohort approach.
The design is particularly advantageous for studying the biologic precursors of diseases.

Conclusions:

The nested case-control design is an efficient and cost-effective alternative to full cohort studies for many research questions.
It is especially powerful for research into the biological origins of diseases and for prevention strategies.
Recommendations include cohort registries, specimen banks, and information clearinghouses to support prevention research.