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Preclinical testing of iopromide. 2nd communication: toxicological evaluation
W Krause1, C Schöbel, W R Press
1Research Laboratories, Schering Aktiengesellschaft, Berlin, Fed. Rep. of Germany.
Arzneimittel-Forschung
|November 1, 1994
Abstract:
Toxicological characteristics of the non-ionic monomeric X-ray contrast agent iopromide (Ultravist, CAS 73334-07-3) were evaluated in rats, rabbits, guinea-pigs and dogs. The scope of investigations included acute toxicity studies, systemic tolerance investigations with repeated applications, reproduction toxicity studies, examinations on the genotoxic and contact-sensitizing potential and local tolerance studies. Iopromide could be shown to be well tolerated in all the tests and species.