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Retroviral determinants of leukemogenesis
G B Athas1, C R Starkey, L S Levy
1Department of Microbiology and Immunology, SL-38, Tulane University School of Medicine, New Orleans, Louisiana 70112.
Critical Reviews in Oncogenesis
|January 1, 1994
Summary
Slowly transforming retroviruses cause cancer through transcriptional regulation, insertional mutagenesis, and viral proteins. This review details these mechanisms in mammalian leukemogenesis.
Area of Science:
- Oncology
- Virology
- Molecular Biology
Background:
- Slowly transforming retroviruses cause malignant diseases in mammals after long incubation periods.
- These retroviruses do not possess a direct oncogene responsible for their oncogenic potential.
Purpose of the Study:
- To review recent findings on the factors contributing to retroviral leukemogenesis.
- To focus on slowly transforming retroviruses in mammals, including humans and experimental animals.
Main Methods:
- Literature review of recent findings on retroviral leukemogenesis.
- Analysis of the roles of specific factors in disease development.
Main Results:
- Retroviral leukemogenesis involves transcriptional regulatory sequences within the long terminal repeat.
- Insertional mutagenesis of cellular protooncogenes is a key mechanism.
- Viral gene-encoded structural and regulatory proteins play significant roles.
Conclusions:
- Retroviral leukemogenesis is a multifactorial process.
- Understanding these factors is crucial for developing therapeutic strategies against retroviral-induced cancers.