Related Experiment Video
Updated: Aug 19, 2026

Spheroid Assay to Measure TGF-β-induced Invasion
Published on: November 16, 2011
The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations
1Cell and Molecular Biology Department, University of California, Berkeley 94720.
Abstract:
From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.
More Related Videos
07:20A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
Published on: February 28, 2020
06:54Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
Related Concept Videos
The Tumor Microenvironment
Regulation of Angiogenesis and Blood Supply
TGF - β Signaling Pathway
Intracellular Signaling Affects Focal Adhesions
Some...