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Epidemiology of tetracycline-resistance determinants
1Dept of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
Trends in Microbiology
|October 1, 1994
Abstract:
Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide range of Gram-positive and Gram-negative bacteria and have reduced the effectiveness of therapy with tetracycline.