[Noninvasive methods in the diagnosis of occupational diseases]

Author's and reported data on the noninvasive methods used in the diagnosis of professional exposures and occupational diseases are reviewed. Noninvasive diagnostic methods include laboratory, physiological, morphological, allergological, etc. methods. Special attention is paid to laboratory methods. Urine, saliva, hairs, nails, teeth, exhaled air, bronchoalveolar lavage fluid, car wax can be used as biosubstrates in which inorganic and organic exogenic compounds, their metabolites or products forming as a result of xenobiotic interaction with cells or molecules of target organ are determined. The significance of laboratory methods for the diagnosis of occupational intoxications and detection of toxic substances in depot is discussed.