Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaine blunts human CD4+ cell activation

F Chiappelli1, P Frost, E Manfrini

  • 1Laboratory of Human Oral and Molecular Immunology, Diagnostic Sciences, UCLA School of Dentistry.

Immunopharmacology
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of one or two successive annual applications of organic fertilisers on the enzyme activity of a soil under barley cultivation.

Bioresource technology·2001
Same author

Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.

Journal of molecular biology·2001
Same author

Comparative in vitro bacteriostatic and bactericidal activity of trovafloxacin, levofloxacin and moxifloxacin against clinical and environmental isolates of Legionella spp.

International journal of antimicrobial agents·2001
Same author

Serum leptin levels in cattle with different nutritional conditions.

Nutrition research (New York, N.Y.)·2001
Same author

A web page to teach neurology and neuropathology to medical students.

Neuropathology and applied neurobiology·2001
Same author

Constituents of Coriaria ruscifolia fruits.

Fitoterapia·2001
Same journal

Papers of the 15th International Conference on Kinins. Part III. Nara, Japan, 19-24 October 1998.

Immunopharmacology·2001
Same journal

Papers from the 15th International Conference on Kinins. Part II. Nara, Japan, 19-24 October 1998.

Immunopharmacology·2001
Same journal

Interleukin 2 maintains biologic stability and sterility over prolonged time.

Immunopharmacology·2000
Same journal

Comparative study of lymphocyte-suppressive potency between prednisolone and methylprednisolone in rheumatoid arthritis.

Immunopharmacology·2000
Same journal

Activation of rat splenic macrophage and lymphocyte functions by fumonisin B1.

Immunopharmacology·2000
Same journal

Sublytic complement attack reduces infarct size in rabbit isolated hearts: evidence for C5a-mediated cardioprotection.

Immunopharmacology·2000
See all related articles

Cocaine impairs early T-cell activation, particularly in CD4+ cells. This immunotoxicity may increase infection risk in HIV-positive individuals with cocaine abuse.

Area of Science:

  • Immunology
  • Pharmacology
  • Cell Biology

Background:

  • Cocaine is known to be immunotoxic, but the precise biochemical mechanisms are not fully understood.
  • Understanding cocaine's effects on T cells is crucial for elucidating its immunopathology.

Purpose of the Study:

  • To investigate the effects of cocaine on human T-cell activation.
  • To elucidate the molecular and cellular mechanisms underlying cocaine-induced immunotoxicity.

Main Methods:

  • Exposure of normal human T cells to varying concentrations of cocaine.
  • Analysis of T-cell responses to different stimuli.
  • Investigation of CD4+ T-cell subpopulations expressing CD62L and their response to beta-endorphin.

Main Results:

Related Experiment Videos

  • Cocaine exposure impairs early activation events in CD4+ T cells but not CD4- T cells.
  • Pre-incubation with beta-endorphin exacerbates cocaine's inhibitory effect on CD4+ T-cell activation.
  • Findings suggest specific molecular pathways affected by cocaine in T cells.

Conclusions:

  • Cocaine significantly modulates T-cell responses, particularly affecting early activation in CD4+ cells.
  • The interaction between cocaine and endogenous opioid peptides may worsen T-cell dysfunction.
  • Cocaine abuse could elevate the risk of opportunistic infections in HIV-seropositive individuals.