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Osteomyelitis caused by Neosartorya pseudofischeri

A A Padhye1, J H Godfrey, F W Chandler

  • 1Emerging Bacterial and Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.

Journal of Clinical Microbiology
|November 1, 1994
PubMed
Summary

This study reports the first case of osteomyelitis caused by Neosartorya pseudofischeri. The fungal infection presented as vertebral lesions in an immunocompromised patient, highlighting a rare fungal pathogen.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Orthopedics

Background:

  • Osteomyelitis, a bone infection, is typically caused by bacteria.
  • Fungal osteomyelitis is rare, especially in immunocompetent individuals.
  • Neosartorya pseudofischeri is a fungus rarely associated with human infections.

Observation:

  • A 77-year-old male with a history of silicosis and tuberculosis presented with vertebral lesions (L2-L3) suspicious for metastasis.
  • Histological examination of vertebral biopsy revealed fungal hyphae.
  • Microscopic analysis identified characteristic ascospores and the anamorph Aspergillus thermomutatus.

Findings:

  • The first documented case of osteomyelitis caused by Neosartorya pseudofischeri is described.
  • Morphological characterization of the fungus, including ascospores and conidial state, confirmed the identification.

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  • The patient's underlying conditions (silicosis, tuberculosis) may have predisposed him to this rare fungal infection.

    • Implications:

    • This case expands the spectrum of known human pathogens within the Neosartorya genus.
    • It underscores the importance of considering fungal etiologies in complex osteomyelitis cases, particularly in patients with risk factors.
    • Further research into the pathogenicity and clinical significance of Neosartorya pseudofischeri in humans is warranted.