Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[VLDL receptor]

J Sakai¹, T Yamamoto

¹Department of Molecular Genetics, University of Texas Southwestern Medical Center.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 1, 1994

Summary

Researchers discovered a new VLDL receptor, similar to the LDL receptor, that binds to apoE-containing lipoproteins. This finding advances understanding of cholesterol and fatty acid metabolism in tissues like heart and muscle.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term outcomes of indocyanine green fluorescence imaging-guided laparoscopic lateral pelvic lymph node dissection for clinical stage II/III middle-lower rectal cancer: a propensity score-matched cohort study.

Techniques in coloproctology·2023

Same author

Evaluation of a high-speed but low-throughput RT-qPCR system for detection of SARS-CoV-2.

The Journal of hospital infection·2020

Same author

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.

Oncogene·2017

Same author

Use of the Oxford Nanopore MinION sequencer for MLST genotyping of vancomycin-resistant enterococci.

The Journal of hospital infection·2017

Same author

Hypophosphatasia: Evaluation of Size and Mineral Density of Exfoliated Teeth.

The Journal of clinical pediatric dentistry·2016

Same author

Immunohistochemical study on IRBP-induced EAU.

Ocular immunology and inflammation·2012

Area of Science:

Biochemistry
Molecular Biology
Lipid Metabolism

Context:

The discovery of the LDL receptor revolutionized understanding of cholesterol homeostasis.
Lipoprotein receptors play a crucial role in lipid transport and metabolism.
Cholesterol and triglyceride-rich lipoproteins are key components of lipid transport.

Purpose:

To identify and characterize a novel lipoprotein receptor involved in lipid metabolism.
To investigate the structure and function of the newly discovered VLDL receptor.
To elucidate the role of the VLDL receptor in fatty acid delivery to peripheral tissues.

Summary:

A second lipoprotein receptor, the VLDL receptor, has been identified, sharing structural similarities with the LDL receptor.
This VLDL receptor specifically binds to apoE-containing lipoproteins.
Abundant VLDL receptor mRNA in heart, muscle, and adipose tissue suggests its role in mediating the uptake of triglyceride-rich lipoproteins.

Impact:

Enhances comprehension of lipoprotein metabolism and cholesterol homeostasis.
Provides insights into the mechanisms of fatty acid uptake by muscle and adipose tissue.
Opens new avenues for research into lipid-related disorders and therapeutic strategies.

Related Experiment Videos