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Synthetic approaches to continuous assays of retroviral proteases
1Department of Structural Biology, Drug Design and Delivery, Abbott Laboratories, Abbott Park, Illinois 60064.
Methods in Enzymology
|January 1, 1994
Abstract:
This chapter has described a number of approaches for continuous assay of retroviral proteases using either chromogenic or fluorogenic synthetic substrates. The significant progress in this area has been catalyzed by the intense interest in HIV protease as a therapeutic target, but these versatile methods will be used widely in future for studies of many other proteases.