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[Amphotericin B level in feces and serum during oral administration in newborns at risk]

R Blaschke-Hellmessen1, R Schwarze

  • 1Institut für Medizinische Mikrobiologie und Hygiene, Medizinischen Fakultät Carl Gustav Carus, Technischen Universität Dresden.

Mycoses
|January 1, 1994
PubMed

Insights

Orally administered amphotericin B (Ampho B) effectively eliminated yeasts in newborns with candidosis. However, prolonged prophylactic use is recommended due to yeast re-isolation post-treatment.

Area of Science:

  • Medical Mycology
  • Neonatal Medicine
  • Pharmacokinetics

Background:

  • Neonatal candidosis poses significant health risks.
  • Oropharyngeal and cutaneous candidosis are common in at-risk newborns.
  • Effective antifungal agents are crucial for managing neonatal yeast infections.

Purpose of the Study:

  • To evaluate the efficacy of oral amphotericin B (Ampho B) in treating neonatal candidosis.
  • To assess yeast elimination and suppression in the orointestinal tract.
  • To determine clinical success and drug concentrations in feces and serum.

Main Methods:

  • A study involving 23 at-risk newborns with candidosis.
  • Administration of Ampho-Moronal suspension for 10 days, with dosage adjusted for weight.
  • Monitoring of amphotericin B concentrations in feces and serum.
  • Mycological analysis of fecal samples before, during, and after treatment.

Main Results:

  • Ampho B was detected in feces (0.6-20 µg/g) and serum (0.06-0.58 µg/ml) in all treated newborns.
  • Initial yeast elimination from feces occurred in 78% of patients.
  • Clinical cure of oral and cutaneous candidosis was observed in 41% of patients.
  • Candida albicans re-isolated in 50% of newborns within 5 days post-treatment.

Conclusions:

  • Oral amphotericin B demonstrates efficacy in reducing yeast colonization in newborns.
  • A significant rate of yeast re-isolation suggests the need for extended prophylactic treatment.
  • Prolonged administration of Ampho-Moronal is recommended during periods of high risk for systemic mycosis.

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