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[Zinc and atherosclerosis]

S Ripa1, R Ripa

  • 1Istituto di Clinica Medica Generale, Università di Ferrara.

Minerva Medica
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

High zinc doses can promote atherosclerosis by altering lipids and blood vessel walls. However, zinc also offers protective antioxidant and calcium-blocking effects, suggesting a therapeutic role in suitable doses.

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Area of Science:

  • Biochemistry
  • Cardiovascular Science

Context:

  • Atherosclerosis is a complex disease involving lipid deposition and vascular inflammation.
  • The role of trace minerals like zinc in cardiovascular health is under investigation.

Purpose:

  • To review the multifaceted relationship between zinc and the development of atherosclerosis.
  • To analyze the mechanisms by which zinc can be both atherogenic and protective.

Summary:

  • High zinc intake can promote atherosclerosis via lipid alterations (decreased HDL, increased LDL), vascular wall damage (hypocupremia-induced), and increased platelet aggregation.
  • Conversely, zinc exhibits antioxidant properties, preventing LDL oxidation and protecting against free radical damage.
  • Zinc's calcium antagonist action and its role in metallothionein regulation offer further protective mechanisms against atherogenesis.

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Impact:

  • Understanding zinc's dual role is crucial for developing effective atherosclerosis prevention and treatment strategies.
  • Suggests that carefully controlled zinc supplementation may hold therapeutic potential for managing atherosclerosis.