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Updated: Oct 13, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Lymphoepithelial carcinoma of the thyroid gland. A thyroid gland carcinoma with thymus-like differentiation]
W Jochum1, B C Padberg, S Schröder
1Departement Pathologie, Universität Zürich.
Abstract:
An example of lymphoepithelial carcinoma of the thyroid is reported, which was first described 10 years ago and has not as yet been documented in the German literature. This tumour is morphologically identical to the lymphoepithelioma of the nasopharynx. In contrast to neoplasms of such morphology occurring in a variety of other organs, the acronym CASTLE--for carcinoma showing thymus-like differentiation--has been proposed by Chan and Rosai for lymphoepithelioma-like carcinomas of the thyroid gland. In this paper, the aforenamed authors' concept of the histogenesis of thyroid tumours with thymic differentiation is presented.
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