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Synthesis and separation of optically active compounds. Part II
Y Gao1, E Boschetti, L Guerrier
1Sepracor Inc., Marlborough, MA 01752.
Annales Pharmaceutiques Francaises
|January 1, 1994
Summary
This review explores chiral chromatography for separating optically active compounds. It details packing materials and their molecular recognition principles for enantiomer preparation, highlighting preparative applications and future trends.
Area of Science:
- Organic Chemistry
- Analytical Chemistry
- Separation Science
Background:
- Optically active compounds are crucial in pharmaceuticals and agrochemicals.
- Enantiomeric separation is a significant challenge in synthesizing chiral molecules.
- Chiral chromatography is a key technique for obtaining pure enantiomers.
Purpose of the Study:
- To review the state-of-the-art in chiral chromatography for enantiomer preparation.
- To describe and classify current packing materials used in chiral chromatography.
- To emphasize the preparative aspects and discuss future developments in the field.
Main Methods:
- Literature review of chiral chromatography techniques and packing materials.
- Classification of chiral stationary phases based on molecular recognition principles.
- Analysis of advantages and disadvantages of different chromatographic phases for specific separations.
Main Results:
- Detailed description and classification of various chiral stationary phases.
- Explanation of molecular recognition mechanisms employed by different phases.
- Evaluation of the suitability of various phases for the preparative separation of enantiomers.
Conclusions:
- Chiral chromatography is an essential tool for enantiomer preparation.
- The choice of packing material significantly impacts separation efficiency and preparative success.
- Further advancements in chiral chromatography promise improved enantioseparation capabilities.