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[The changes on cerebral hemodynamics during selective cerebral perfusion cooling]
1Second Department of Surgery, Niigata University School of Medicine, Japan.
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
|December 1, 1994
Summary
Slow changes in blood temperature during cardiopulmonary bypass and selective cerebral perfusion minimize adverse effects on cerebral hemodynamics. Rapid temperature fluctuations significantly impact cerebral blood flow and pressure, highlighting the importance of controlled cooling and rewarming protocols.
Area of Science:
- Physiology
- Cardiovascular Science
- Neurology
Context:
- Investigating the physiological responses to varying rates of blood temperature change during cardiopulmonary bypass (CPB) and selective cerebral perfusion (SCP).
- Understanding the impact of rapid versus slow cooling and rewarming protocols on cerebral hemodynamics in a porcine model.
Purpose:
- To evaluate the influence of different blood temperature change rates (rapid vs. slow) on cerebral hemodynamic parameters.
- To compare the effects of rapid and slow temperature changes on intracranial pressure (ICP), carotid arterial flow (CAF), carotid arterial pressure (CAP), and PCO2 during CPB and SCP.
Summary:
- Rapid cooling during CPB elevated CAP and decreased CAF, ICP, and PCO2. Rapid rewarming significantly increased CAF and ICP.
- Slow temperature changes during CPB and SCP did not induce significant alterations in CAP, CAF, ICP, or PCO2.
- Rapid temperature changes during SCP notably decreased CAP and altered CAF and ICP, whereas slow changes had minimal impact.
Impact:
- The findings suggest that slow cooling and rewarming protocols exert less influence on cerebral hemodynamics compared to rapid changes.
- This research informs the optimization of temperature management strategies during cardiac surgery to mitigate neurological complications.