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Hyperthermia for bone and soft tissue sarcoma: relationship between computerized tomographic and histological
I Tsukiyama1, T Ogino, S Egawa
1Department of Radiation Therapy, Tochigi Cancer Center Hospital, Japan.
Radiation Medicine
|September 1, 1994
Summary
Hyperthermia combined with radiotherapy or chemotherapy shows a 48% response rate for bone and soft tissue sarcomas. Tumor size impacts heating effectiveness, but low-density areas on CT scans correlate with temperature, suggesting potential for improved treatment evaluation.
Area of Science:
- Oncology
- Medical Physics
Background:
- Bone and soft tissue sarcomas present treatment challenges.
- Hyperthermia is an emerging therapeutic modality.
Purpose of the Study:
- To evaluate the efficacy of hyperthermia combined with radiotherapy or chemotherapy in treating bone and soft tissue sarcomas.
- To explore correlations between imaging parameters and treatment outcomes.
Main Methods:
- Retrospective analysis of 38 patients (44 tumors) treated between 1983-1992.
- Hyperthermia administered concurrently with radiotherapy or chemotherapy.
- Computed Tomography (CT) imaging used to assess tumor characteristics.
Main Results:
- Overall response rate of 48% (21/44 tumors).
- No significant correlation between heating duration/temperature and local effect.
- Correlation observed between low-density areas on CT and maximum temperature.
- Response rates increased to over 65% when considering partial and complete necrosis.
Conclusions:
- Hyperthermia is a viable option for bone and soft tissue sarcomas when combined with standard therapies.
- Tumor size can limit effective hyperthermia application.
- CT-based low-density assessment shows potential for treatment response prediction but requires careful validation.