Microvascular thrombosis in the pathogenesis of chronic renal disease

Haemostatic involvement in the pathophysiology of renal disease has been evaluated kinetically. Renal microvascular platelet destruction is characteristic of several different pathologic processes in which there is damage to intrarenal endothelial cells. The hemostatic abnormalities may be partly modifiable by drugs which inhibit platelet function, rather than by anticoagulant, but there is as yet no evidence that interruption of platelet consumption will cause improvement in renal function.