Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between mivacurium and succinylcholine

O Erkola1, P Rautoma, O A Meretoja

  • 1Department of Anaesthesia, Maria Hospital of Helsinki City Hospital, Finland.

Anesthesia and Analgesia
|March 1, 1995
PubMed
Summary

This study found that succinylcholine has minimal impact on how mivacurium affects neuromuscular function in healthy patients. Recovery from mivacurium block showed slightly faster T1 times but greater fade after succinylcholine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitigating on-call symptoms through organizational justice and job control: a cross-sectional study among Finnish anesthesiologists.

Acta anaesthesiologica Scandinavica·2009
Same author

Suicidality among Finnish anaesthesiologists.

Acta anaesthesiologica Scandinavica·2009
Same author

We should work less at night.

Acta anaesthesiologica Scandinavica·2009
Same author

Attitudes to job turnover among Finnish anaesthetists.

Occupational medicine (Oxford, England)·2009
Same author

Job satisfaction, work ability and life satisfaction among Finnish anaesthesiologists.

Acta anaesthesiologica Scandinavica·2007
Same author

Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children.

Acta anaesthesiologica Scandinavica·2007

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Neuromuscular Blockade

Background:

  • Understanding drug interactions is crucial for safe anesthesia.
  • Mivacurium and succinylcholine are commonly used neuromuscular blocking agents.
  • Investigating their combined effects is important for clinical practice.

Purpose of the Study:

  • To investigate the interaction between mivacurium and succinylcholine.
  • To determine the effect of early succinylcholine recovery on subsequent mivacurium administration.
  • To assess neuromuscular function using electromyography.

Main Methods:

  • 40 adult patients undergoing propofol-alfentanil-N2O-O2 anesthesia were studied.
  • Neuromuscular function monitored via electromyography (Relaxograph).

Related Experiment Videos

  • Patients received either succinylcholine followed by mivacurium, or mivacurium alone.

    • Main Results:

    • No significant difference in mivacurium onset time or maximal block between groups.
    • Slightly shorter T1 recovery times for mivacurium after succinylcholine (P < 0.05).
    • Greater fade and lower train-of-four (TOF) ratio during mivacurium recovery post-succinylcholine.

    Conclusions:

    • Succinylcholine has negligible effects on subsequent mivacurium-induced neuromuscular block in healthy patients.
    • While some recovery parameters differ slightly, overall clinical impact is minimal.
    • Further research may explore specific patient populations or varying dosages.