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Non-fluoride anticaries agents

¹SmithKline Beecham Research and Technical Services Centre, Weybridge, Surrey, UK.

Advances in Dental Research

|July 1, 1994

Summary

This summary is machine-generated.

Researchers reviewed non-fluoride anticaries agents, finding that those modifying plaque acid production, like phosphates, show promise. Some agents, such as calcium glycerophosphate, enhance fluoride

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Area of Science:

Dental Research
Cariology
Preventive Dentistry

Background:

Numerous anticaries agents beyond fluoride have been identified through laboratory, animal, and human studies.
This review focuses on agents demonstrating significant efficacy in preclinical or clinical anticaries models.

Purpose of the Study:

To review and categorize non-fluoride anticaries agents.
To assess the potential of these agents for human application and combination therapies.

Main Methods:

Systematic review of literature on anticaries agents.
Categorization of agents into phosphorus-containing, calcium-containing, antimicrobials/antibiotics, metals, and miscellaneous groups.
Evaluation of evidence from animal caries models, in situ models, and human clinical trials.

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Main Results:

Many agents show promise in laboratory and animal models, but few advance to human trials.
Chlorhexidine is a notable exception with demonstrated clinical efficacy.
Agents like calcium glycerophosphate can enhance fluoride's anticaries effect.
Phosphates show promise as dietary additives for caries prevention.

Conclusions:

Non-fluoride agents that modify plaque acid production (antimicrobially or biochemically) are most promising for topical use.
Combined therapies, particularly with fluoride, may offer enhanced anticaries benefits.
Further research into non-fluoride agents, especially phosphates, is warranted for caries prevention strategies.