Related Experiment Videos
Organization of the human serotonin transporter gene
K P Lesch1, U Balling, J Gross
1Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Journal of Neural Transmission. General Section
|January 1, 1994
Abstract:
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.