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Thyroid function during pregnancy with special reference to hydatidiform mole and hyperemesis

T Bruun, K Kristoffersen

    Acta Endocrinologica
    |June 1, 1978
    PubMed
    Summary
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    Pregnant women with hydatidiform mole or hyperemesis gravidarum show altered thyroid function tests, including elevated protein-bound iodine (PBI) and triiodothyronine (T3) levels. These changes suggest a potential common cause for thyroid stimulation in these conditions.

    Area of Science:

    • Endocrinology
    • Obstetrics
    • Reproductive Medicine

    Background:

    • Thyroid function is crucial during pregnancy.
    • Hyperemesis gravidarum and hydatidiform mole are associated with physiological changes.
    • Understanding thyroid alterations in these conditions is important for maternal health.

    Purpose of the Study:

    • To investigate thyroid function in pregnant women with hyperemesis gravidarum and hydatidiform mole.
    • To compare thyroid function test results across different pregnancy groups.
    • To explore potential correlations between molar tissue volume and thyroid markers.

    Main Methods:

    • Measurement of serum protein-bound iodine (PBI), triiodothyronine reaction (T3-test), and serum cholesterol.
    • Analysis of data from three groups: normal pregnancy, hyperemesis, and hydatidiform mole.

    Related Experiment Videos

  • Correlation analysis between molar tissue volume and PBI levels.

    • Main Results:

    • Patients with hydatidiform mole exhibited high PBI and T3-test values, with low cholesterol.
    • Nearly one-third of hyperemesis patients showed similar thyroid function test patterns.
    • A positive correlation was found between molar tissue volume and PBI levels.
    • Hyperemesis treatment often normalized thyroid tests, unlike in mole cases.

    Conclusions:

    • Hydatidiform mole and hyperemesis gravidarum may share a common mechanism for thyroid stimulation.
    • Elevated PBI and T3-test with low cholesterol are characteristic of hydatidiform mole.
    • Thyroid function monitoring is essential in complicated pregnancies.