Related Experiment Videos
Animal models of Lyme disease: pathogenesis and immunoprophylaxis
1Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.
Trends in Microbiology
|November 1, 1994
Abstract:
Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.