Necrotizing myelopathy--a report of two cases with review of literature
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V V Radhakrishnan1, A Saraswathy, P K Mohan
1Department of Pathology and Neurology, Shree Chitra Tirunal Institute for Medical Sciences and Technology Trivendram.
Abstract:
Necrotizing myelopathy is an uncommon neurological disorder. Till 1991, only 31 cases have been described in the literature. In this report, clinical and neuropathological features in two patients with necrotizing myelopathy are described. The precise aetiological agent in first patient was undetermined, However in the second patient there was serological evidence, suggestive of Herpes simplex virus infection.
Insights
Necrotizing myelopathy is a rare neurological condition. This report details two cases, with one potentially linked to Herpes simplex virus, highlighting the need for further research into its causes.
Area of Science:
- Neurology
- Pathology
Background:
- Necrotizing myelopathy is an uncommon neurological disorder.
- Limited cases (31) reported by 1991.
Observation:
- This report describes clinical and neuropathological features in two patients.
- Patient 1: Undetermined aetiological agent.
- Patient 2: Serological evidence suggestive of Herpes simplex virus infection.
Findings:
- Detailed clinical and neuropathological analysis of two necrotizing myelopathy cases.
- Identification of potential viral aetiology (Herpes simplex virus) in one case.
- Highlights diagnostic challenges due to undetermined causes in some instances.
Implications:
- Contributes to understanding the spectrum of necrotizing myelopathy.
- Suggests Herpes simplex virus as a potential cause, warranting further investigation.
- Emphasizes the importance of comprehensive neuropathological examination in diagnosing rare neurological disorders.