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Related Experiment Videos

Vitamin E does not prevent exercise-induced increase in pulmonary clearance

A M Lorino1, M Paul, L Cocea

  • 1Institut National de la Santé et de la Recherche Médicale Unité 296, Département de Physiologie, Créteil, France.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1994
PubMed
Summary

Sustained exercise increases lung epithelial permeability. Vitamin E supplementation did not alter this effect, suggesting lipid peroxidation is not the primary cause of exercise-induced lung permeability changes.

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Area of Science:

  • Exercise Physiology
  • Pulmonary Medicine
  • Cellular Biology

Background:

  • Sustained exercise is known to increase alveolar epithelial permeability.
  • The exact mechanism behind this exercise-induced permeability increase remains unclear.
  • Lipid peroxidation has been hypothesized as a potential contributing factor.

Purpose of the Study:

  • To investigate the role of lipid peroxidation in exercise-induced increases in alveolar epithelial permeability.
  • To determine if vitamin E supplementation can mitigate exercise-induced changes in lung permeability.

Main Methods:

  • A single-blind crossover study involving seven healthy volunteers.
  • Pulmonary clearance of aerosolized 99mTc-labeled diethylenetriaminepentaacetate (99mTc-DTPA) was measured.

Related Experiment Videos

  • Exercise consisted of 60 minutes on a treadmill at 80% maximal oxygen uptake.
  • Measurements were taken before and after a 3-week supplementation with oral vitamin E (1,000 IU/day).

    • Main Results:

    • Vitamin E supplementation did not significantly reduce the exercise-induced increase in pulmonary 99mTc-DTPA clearance.
    • The findings suggest that lipid peroxidation is not the primary mechanism responsible for the observed increase in lung permeability.

    Conclusions:

    • The exercise-induced increase in lung epithelial permeability is unlikely to be primarily caused by lipid peroxidation.
    • Results support the hypothesis that mechanical effects of hyperventilation on intercellular tight junctions may be the main driver of increased lung permeability during exercise.