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Prolactin in systemic lupus erythematosus
R Pauzner1, M B Urowitz, D D Gladman
1University of Toronto Rheumatic Disease Unit, Wellesley Hospital, ON, Canada.
Objective:
To estimate the prevalence and evaluate the clinical significance of hyperprolactinemia in a cohort of 82 consecutively reviewed patients with systemic lupus erythematosus (SLE).
Methods:
Basal prolactin levels and clinical data were analyzed in 82 consecutive patients with SLE, and longitudinal studies were carried out in 30/82 patients.
Results:
Hyperprolactinemia was not associated with active disease in the group as a whole (p = 0.145) or in longitudinal studies in 30 patients (p = 0.294). However, SLE was more often active in patients with hyperprolactinemia without any obvious causes (8/9 samples) compared with patients with known secondary causes for hyperprolactinemia (p = 0.088).
Conclusion:
Hyperprolactinemia is likely not associated with disease activity in SLE.