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Hydranencephaly in two rhesus monkeys (Macaca mulatta)

A A Binhazim¹, S J Buchl

¹University of Texas M. D. Anderson Cancer Center, Science Park.

Journal of Medical Primatology

|July 1, 1994

Summary

Spontaneous hydranencephaly, a severe brain malformation, was observed in two stillborn rhesus macaque fetuses. This finding highlights a rare congenital condition in non-human primates.

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Area of Science:

Veterinary Pathology
Developmental Biology
Primate Research

Background:

Hydranencephaly is a rare congenital brain disorder characterized by the absence of the cerebral hemispheres.
Understanding the etiology and occurrence of congenital malformations in non-human primates is crucial for both veterinary and biomedical research.
Rhesus macaques (Macaca mulatta) are widely used models in biomedical research, making spontaneous conditions in this species particularly relevant.

Observation:

Two stillborn rhesus macaque fetuses were delivered from young females.
Necropsy revealed severe brain abnormalities consistent with hydranencephaly.
Histological examination confirmed the diagnosis of hydranencephaly.

Findings:

Spontaneous hydranencephaly was diagnosed in two stillborn fetuses.
The condition was confirmed through both gross necropsy and histological analysis.
This represents a naturally occurring case of hydranencephaly in Macaca mulatta.

Implications:

This case report contributes to the understanding of rare congenital malformations in primates.
The findings may inform veterinary care and reproductive management in captive macaque colonies.
Further research into the potential causes of spontaneous hydranencephaly in this species may be warranted.

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