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Related Experiment Videos

Are hypertensives hypercoagulable?

M A Miller1, C R Spillert, R Ponnudurai

  • 1Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103-2757.

Journal of the National Medical Association
|January 1, 1995
PubMed
Summary
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Many hypertensive patients exhibit hypercoagulable blood, increasing their risk for myocardial infarction. The modified recalcification time (MRT) test identified this heightened risk in hypertensives, suggesting a need for closer monitoring.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Thrombosis Research

Background:

  • Angiotensin II, a vasoconstrictor, is linked to prothrombotic activity.
  • Hypertension is increasingly recognized as a condition associated with hypercoagulability and elevated risk for myocardial infarction.

Purpose of the Study:

  • To investigate the prevalence of hypercoagulability in hypertensive individuals.
  • To assess the utility of the modified recalcification time (MRT) test in identifying hypercoagulability in hypertension.

Main Methods:

  • The modified recalcification time (MRT) test was employed, assessing blood samples from hypertensive patients and normotensive controls.
  • Blood samples were incubated with and without endotoxin to evaluate tissue factor's role in coagulation.
  • MRT values were determined for both groups (MRT S and MRT E) to quantify coagulation time.

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Main Results:

  • The MRT E values were significantly shorter in hypertensives (4.3 +/- 1.2 minutes) compared to controls (5.7 +/- 0.9 minutes).
  • Hypertensives with MRT E values below 4.5 minutes were classified as hypercoagulable.
  • No significant difference was observed in MRT S values between hypertensives and controls.

Conclusions:

  • The modified recalcification time (MRT) test, specifically MRT E, effectively identifies hypercoagulability in hypertensive patients.
  • Hypercoagulability, indicated by short MRT E values, represents a significant risk factor for thrombotic events, including myocardial infarction, in hypertensive individuals.