Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Signal transduction. Just another signalling pathway

J Briscoe¹, D Guschin, M Müller

¹Imperial Cancer Research Fund Laboratories, 23, 44 Lincoln's Inn Fields, London, UK.

Current Biology : CB

|November 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and Assessment of an AI-based Machine Learning Model for Predicting Urinary Continence and Erectile Function Recovery after Robotic-Assisted Radical Prostatectomy: Insights from a Prostate Cancer Referral Center.

Computer methods and programs in biomedicine·2024

Same author

Dynamical landscapes of cell fate decisions.

Interface focus·2022

Same author

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis.

Nature biotechnology·2021

Same author

Non-volatile electrically-driven repeatable magnetization reversal with no applied magnetic field.

Nature communications·2013

Same author

Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.

Cell death and differentiation·2011

Same author

Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development.

Methods in molecular biology (Clifton, N.J.)·2010

The JAK-STAT pathway is crucial for cytokine signaling at the cell surface. This pathway helps explain why cytokines have diverse and overlapping effects.

Area of Science:

Cellular biology
Molecular signaling
Immunology

Background:

Cytokines are critical signaling molecules in cellular communication.
The mechanisms underlying cytokine pleiotropy and redundancy require elucidation.

Purpose of the Study:

To investigate the role of the JAK-STAT pathway in cytokine signaling.
To understand how this pathway contributes to the diverse effects of cytokines.

Main Methods:

Analysis of the JAK-STAT signal transduction pathway.
Investigating cytokine receptor interactions at the cell surface.

Main Results:

The JAK-STAT pathway is a key mediator of cytokine signal transduction.
This pathway partially explains the pleiotropic and redundant actions of cytokines.

Related Experiment Videos

Conclusions:

The JAK-STAT pathway is central to cellular responses to cytokines.
Understanding this pathway offers insights into cytokine network complexity.