Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated cerebrospinal fluid proteins in sciatica caused by disc herniation

J S Skouen1, J L Larsen, E Vollset

  • 1Radiological Section, Haukeland University Hospital, Bergen, Norway.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|January 1, 1994
PubMed
Summary

Sciatica patients show elevated cerebrospinal fluid (CSF) proteins, indicating a plasma leak. This protein elevation, particularly albumin and IgG, is more pronounced in men with sciatica.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal changes of serum cytokines in patients with chronic low back pain and Modic changes.

Osteoarthritis and cartilage·2023
Same author

Intramedullary spinal cord and filum tumours-long-term outcome: single institution case series.

Acta neurochirurgica·2022
Same author

Long-term neurological sequelae after decompression sickness in retired professional divers.

Journal of the neurological sciences·2022
Same author

Diving and long-term cardiovascular health.

Occupational medicine (Oxford, England)·2017
Same author

Pregnancy outcome in partners of male professional divers in Norway.

Occupational medicine (Oxford, England)·2016
Same author

Subjective health complaints predict functional outcome six months after stroke.

Acta neurologica Scandinavica·2016

Area of Science:

  • Neurology
  • Biochemistry

Background:

  • Sciatica, often caused by lumbar disc herniation, can lead to changes in cerebrospinal fluid (CSF) composition.
  • Understanding protein alterations in CSF is crucial for elucidating disease mechanisms.

Purpose of the Study:

  • To investigate the degree and mechanisms of protein elevations in the CSF of patients with sciatica.
  • To compare CSF protein levels between patients with sciatica and control subjects.

Main Methods:

  • Analysis of cerebrospinal fluid (CSF) and serum samples from 180 patients with sciatica and 63 control subjects.
  • Measurement of CSF/serum albumin ratios, CSF/serum IgG ratios, and total CSF protein concentrations.

Main Results:

  • Patients with sciatica exhibited significantly higher CSF/serum albumin and IgG ratios, and total CSF protein concentrations compared to controls.

Related Experiment Videos

  • Elevated protein ratios were more pronounced in male patients than in female patients.
  • Higher CSF/serum albumin and IgG ratios were also observed in men within the control group.

    • Conclusions:

    • The findings suggest a blood-brain barrier leak, allowing plasma proteins like albumin and IgG to enter the CSF in sciatica patients.
    • The observed protein leak is more significant in men.
    • Sex-based differences in protein ratios warrant further investigation in both healthy individuals and those with neurological conditions.