Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early decrease of serum Clara cell protein in silica-exposed workers

A M Bernard1, J M Gonzalez-Lorenzo, E Siles

  • 1Unit of Industrial Toxicology and Occupational Medicine, Catholic University of Louvain, Faculty of Medicine, Brussels, Belgium.

The European Respiratory Journal
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population monitoring for genetic damage induced by environmental physical and chemical agents.

Environmental monitoring and assessment·2013
Same author

Interaction between PARP-1 and HIF-2α in the hypoxic response.

Oncogene·2013
Same author

Development and characterization of 11 novel microsatellite loci for the roundscale spearfish Tetrapturus georgii and their cross-species amplification among other istiophorid species.

Journal of fish biology·2012
Same author

Effects of retinoic acid, auranofin and mercuric chloride on plasminogen activator activity in post-implantation cultured mouse embryos.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The interaction of cobalt metal with different carbides and other mineral particles on mouse peritoneal macrophages.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The nitric oxide system response to hypoxia/reoxygenation in the aged cerebral cortex.

Experimental gerontology·2007

Serum Clara cell protein (CC16) levels decreased in silica-exposed miners, indicating early respiratory epithelial damage. This suggests CC16 is a sensitive marker for detecting harmful respiratory exposures.

Area of Science:

  • Environmental Health
  • Biochemistry
  • Occupational Medicine

Background:

  • Clara cell protein (CC16) is secreted by the respiratory epithelium.
  • CC16 is proposed as a marker for respiratory epithelial injury.
  • Silica dust exposure is a significant occupational hazard.

Purpose of the Study:

  • To investigate serum and sputum CC16 concentrations in silica-exposed miners.
  • To evaluate CC16 as a potential biomarker for early silica-induced respiratory damage.

Main Methods:

  • Serum and sputum CC16 levels were measured in 86 silica-exposed miners and 86 matched controls.
  • Subjects were stratified by smoking status (nonsmokers and current smokers).
  • Respiratory symptoms, chest radiographs, and lung function tests were assessed.

Related Experiment Videos

Main Results:

  • Serum CC16 was significantly lower in silica-exposed workers compared to controls.
  • This reduction was observed in both nonsmokers and smokers.
  • Sputum CC16 levels were also reduced in exposed workers.
  • No differences in respiratory symptoms or lung function were detected between groups.

Conclusions:

  • Reduced serum CC16 concentrations likely indicate early toxic effects of silica on the respiratory epithelium.
  • CC16 is a sensitive biomarker for detecting silica exposure and potential respiratory harm.
  • CC16 determination may aid in early detection of occupational lung injury.