Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The epithelial barrier function in clear corneal grafts

S W Chang1, F R Hu

  • 1Department of Ophthalmology, National Taiwan University Hospital, Taipei, ROC.

Ophthalmic Research
|January 1, 1994
PubMed
Summary

Corneal grafts show higher permeability and reduced sensitivity, indicating impaired barrier function and reinnervation years after transplantation, even with clear grafts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upper airway disease in Jeju Haenyeo: the aging and resilience cohort (JH-ARC) study.

Rhinology·2026
Same author

[Analysis of peripheral retinal defocus and wavefront aberrations in children with unilateral myopic anisometropia].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2025
Same author

Retraction notice to "Advances in bioremediation of emerging contaminants from industrial wastewater by oxidoreductase enzymes" [Bioresour. Technol. 359 (2022) 127444].

Bioresource technology·2025
Same author

Retraction notice to "Cleaner production of agriculturally valuable benignant materials from industry generated bio-wastes: A review" [Bioresour. Technol. 320 (2021) 124281].

Bioresource technology·2025
Same author

Epithelial-mesenchymal transition profiles in triple negative breast carcinoma may explain its aggressive nature.

The Malaysian journal of pathology·2023
Same author

Development of the control system for electron cyclotron resonance heating on J-TEXT tokamak.

The Review of scientific instruments·2023

Area of Science:

  • Ophthalmology
  • Corneal Research
  • Transplantation Science

Background:

  • Penetrating keratoplasty (corneal transplantation) is a common procedure.
  • Assessing the long-term functional integrity of corneal grafts is crucial.

Purpose of the Study:

  • To evaluate corneal epithelial barrier function and sensitivity in patients with clear corneal grafts.
  • To compare graft function with normal fellow eyes.

Main Methods:

  • Fluorophotometry was used to measure corneal epithelial permeability.
  • Corneal sensitivity was assessed using a standardized test.
  • 93 grafted eyes and 65 control fellow eyes were analyzed.

Main Results:

  • Grafted corneas exhibited significantly higher epithelial permeability compared to control eyes (p < 0.001).
  • A paired analysis confirmed significantly greater permeability in grafted corneas versus their healthy fellow eyes (p = 0.006).
  • Corneal sensitivity was significantly reduced in grafted corneas (hypesthesia).

Conclusions:

  • Clear corneal grafts often present with subnormal epithelial barrier function.
  • Impaired reinnervation is common in corneal grafts, even years post-transplantation.
  • These functional deficits persist despite a clinically normal appearance.

Related Experiment Videos