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Related Experiment Videos

Is atherosclerosis an immunologically mediated disease?

G Wick1, G Schett, A Amberger

  • 1Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck.

Immunology Today
|January 1, 1995
PubMed
Summary

Atherosclerosis initiation involves an autoimmune response to heat shock protein 60 (Hsp60). This early inflammatory stage is reversible, even in children, but can progress with additional risk factors.

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Area of Science:

  • Immunology
  • Cardiovascular Research
  • Pathology

Background:

  • Atherosclerosis is traditionally viewed as a lipid-driven disease.
  • Emerging evidence suggests early stages are inflammatory.
  • Endothelial cells express heat shock protein 60 (Hsp60) under stress.

Purpose of the Study:

  • To investigate the role of autoimmune reactions against Hsp60 in the initiation of atherosclerosis.
  • To identify the initiating event in atherogenesis.

Main Methods:

  • Analysis of humoral and T-cell-mediated immune responses.
  • Observation of Hsp60 expression in endothelial cells under haemodynamic stress.

Main Results:

  • Evidence of both humoral and T-cell-mediated immune responses against Hsp60 early in disease.

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  • Hsp60 is expressed by endothelial cells in areas of increased haemodynamic stress.
  • The initial inflammatory stage is reversible and observed even in children.

    • Conclusions:

    • An autoimmune reaction against Hsp60 is proposed as the initiating event in atherogenesis.
    • Early inflammatory changes are reversible.
    • Progression to advanced atherosclerosis depends on the presence of additional risk factors like high cholesterol, smoking, and obesity.