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Ki-1 (CD30)-positive large cell lymphoma presented with leukemia: a case report
Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|December 1, 1994
Summary
This case report details a rare leukemic phase of Ki-1 positive large cell lymphoma in a 77-year-old woman. The findings highlight the importance of considering this lymphoma in differential diagnoses for unexplained anemia and abnormal lymphoid cells.
Area of Science:
- Hematology
- Oncology
- Immunophenotyping
Background:
- Anaplastic large cell lymphoma (ALCL) is a distinct type of non-Hodgkin lymphoma.
- Ki-1 (CD30) positivity is a hallmark of ALCL, typically affecting lymph nodes.
- Leukemic presentation of ALCL is uncommon.
Observation:
- A 77-year-old woman presented with fatigue and fever, diagnosed with anemia and abnormal lymphoid cells.
- Peripheral blood and bone marrow revealed diffuse infiltration by these atypical lymphoid cells.
- Immunophenotypic analysis identified the cells as T-cell lineage, positive for CD30 (Ki-1), CD3, HLA-DR, and CD25.
Findings:
- The patient was diagnosed with the leukemic phase of Ki-1 positive large cell lymphoma.
- Differential diagnoses considered included acute megakaryocytic leukemia, malignant histiocytosis, and other lymphomas.
- The T-cell lineage was confirmed, distinguishing it from B-cell lymphomas.
Implications:
- This case underscores the rare but possible leukemic manifestation of Ki-1 positive large cell lymphoma.
- It emphasizes the need to include this diagnosis in the differential for patients with unexplained bone marrow or peripheral blood abnormalities.
- Accurate immunophenotypic analysis is crucial for correct diagnosis and management of such rare hematologic malignancies.
