Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pax genes in development

A Mansouri1, A Stoykova, P Gruss

  • 1Max-Plank-Institut für biophysikalische Chemie, Abteilung Molekulare Zellbiologie, Göttingen, Germany.

Journal of Cell Science. Supplement
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute presentation of cocoon abdomen as intestinal obstruction mimicking with strangulated eventration: A case report.

International journal of surgery case reports·2024
Same author

[Ultrawide-field fundus photography showing frosted branch angiitis].

Journal francais d'ophtalmologie·2024
Same author

Clinophobia: Dermatologists on the front line (16 cases).

Annales de dermatologie et de venereologie·2021
Same author

WITHDRAWN: Incidence and mortality of COVID-19 in Iranian multiple sclerosis patients treated with disease-modifying therapies.

Revue neurologique·2020
Same author

Increasing the activity of copper exchanged mordenite in the direct isothermal conversion of methane to methanol by Pt and Pd doping.

Chemical science·2019
Same author

[Is the ureteral length associated with the patient's size?]

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2019
Same journal

Does the Wilms' tumour suppressor gene, WT1, play roles in both splicing and transcription?

Journal of cell science. Supplement·1995
Same journal

Regulation of transcription by E2F1/DP1.

Journal of cell science. Supplement·1995
Same journal

Regulation of cell proliferation and differentiation by Myc.

Journal of cell science. Supplement·1995
Same journal

Appearance of apparently ubiquitin-conjugated I kappa B-alpha during its phosphorylation-induced degradation in intact cells.

Journal of cell science. Supplement·1995
Same journal

Recognition and processing of damaged DNA.

Journal of cell science. Supplement·1995
Same journal

Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle.

Journal of cell science. Supplement·1995
See all related articles

The Pax gene family, crucial for embryonic development, includes nine members. Mutations in specific Pax genes are linked to developmental disorders in both mice and humans, highlighting their essential roles.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The Pax gene family comprises nine members encoding nuclear transcription factors.
  • These genes exhibit temporally and spatially restricted expression patterns during embryogenesis.
  • Their expression patterns suggest a critical role in embryonic development.

Purpose of the Study:

  • To investigate the role of Pax genes in embryonic development.
  • To highlight the connection between Pax gene mutations and developmental abnormalities.

Main Methods:

  • Analysis of mouse developmental mutants.
  • Correlation with human genetic syndromes.
  • Identification of mutations in specific Pax genes.

Related Experiment Videos

Main Results:

  • Three Pax genes are mutated in mouse developmental mutants: undulated, Splotch, and small eye.
  • Pax-3 mutations are associated with Waardenburg syndrome in humans.
  • Pax-6 mutations are linked to aniridia in humans.

Conclusions:

  • Pax genes play a vital role in embryonic development.
  • Mutations in Pax genes lead to specific developmental disorders.
  • Studying Pax gene mutations provides insights into developmental processes and associated human syndromes.