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Inositol phosphates have novel anticancer function

A M Shamsuddin1

  • 1Department of Pathology, University of Maryland School of Medicine, Baltimore 21201-1192.

The Journal of Nutrition
|March 1, 1995
PubMed
Summary
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Inositol hexaphosphate (InsP6), found in plant foods, shows significant anticancer potential by reducing cancer cell proliferation and promoting differentiation. This discovery may explain the cancer-lowering effects of high-fiber diets.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Inositol hexaphosphate (InsP6), also known as phytic acid, is abundant in plant-based foods like cereals and legumes.
  • InsP6 and its derivatives (InsP1-5) are present in mammalian cells, regulating crucial cellular functions.
  • Epidemiological studies link high-fiber diets, rich in InsP6, to reduced cancer incidence.

Purpose of the Study:

  • To investigate the anticancer potential of InsP6, both preventively and therapeutically.
  • To explore the mechanisms by which InsP6 affects cancer cells.
  • To correlate dietary InsP6 intake with cancer risk reduction.

Main Methods:

  • In vivo and in vitro experiments were conducted.
  • InsP6 absorption, distribution, and cellular uptake were studied in rats and malignant cell lines.

Related Experiment Videos

  • The effects of InsP6 on cell proliferation and differentiation were analyzed.

    • Main Results:

    • InsP6 demonstrated significant anticancer effects, reducing cell proliferation and increasing malignant cell differentiation towards a normal phenotype.
    • InsP6 is rapidly absorbed and dephosphorylated within cells, suggesting its lower forms mediate its action.
    • Dietary InsP6 may partially explain the cancer-protective effects of high-fiber diets.

    Conclusions:

    • InsP6 exhibits promising anticancer properties, warranting its consideration in cancer prevention and therapy strategies.
    • Further research is needed to fully elucidate the mechanisms of InsP6's action.
    • The findings support the role of dietary InsP6 in cancer risk reduction.